Arecoline induced disruption of expression and localization of the tight junctional protein ZO-1 is dependent on the HER 2 expression in human endometrial Ishikawa cells |
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| Authors: | Sarbani Giri Kevin M Poindexter Shyam N Sundar Gary L Firestone |
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| Institution: | (1) Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA;(2) Department of Life Science, Assam University, Silchar, Assam, 788011, India |
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| Abstract: | Background Approximately 600 million people chew Betel nut, making this practice the fourth most popular oral habit in the world. Arecoline,
the major alkaloid present in betel nut is one of the causative agents for precancerous lesions and several cancers of mouth
among those who chew betel nut. Arecoline can be detected in the human embryonic tissue and is correlated to low birth weight
of newborns whose mothers chew betel nut during pregnancy, suggesting that arecoline can induce many systemic effects. However,
few reports exist as to the effects of arecoline in human tissues other than oral cancer cell lines. Furthermore, in any system,
virtually nothing is known about the cellular effects of arecoline treatment on membrane associated signaling components of
human cancer cells. |
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