Chromosome localization of the human oncogene INT1 to 12q13 by in situ hybridization |
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| Authors: | K Arheden N Mandahl B Str?mbeck M Isaksson F Mitelman |
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| Institution: | Department of Clinical Genetics, University Hospital, Lund, Sweden. |
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| Abstract: | The human oncogene INT1 has been mapped to chromosome band 12q13 by in situ hybridization. The precise localization of this gene is of particular interest, since the region 12q13----q14 has been reported to be involved in chromosomal rearrangements in lipomas, myxoid liposarcomas, pleomorphic adenomas, and myomas. The involvement of this region in both benign and malignant tumors suggests a common pathogenetic pathway in which changes affecting INT1 may be an important step. |
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