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Structural insights into the function of the catalytically active human Taspase1
Affiliation:1. Center for Applied Structural Discovery, Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA;2. Beryllium Discovery Corp., with present address of UCB Biosciences, Bedford, MA 01730, USA;3. Division of Biosciences, SRI International Menlo Park, Menlo Park, CA 94025, USA;4. Eyring Materials Center, Arizona State University, Tempe, AZ 85257, USA;5. Chemical Engineering, School for Engineering of Matter, Transport, and Energy, Arizona State University, Tempe, AZ 85287, USA;6. Molecular Oncology, Division of Oncology, Department of Medicine, Washington University, St. Louis, MO 63110, USA;7. Frederick National Lab for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA;8. Department of Crystallography and Structural Biology, Institute of Physical-Chemistry "Rocasolano", Spanish National Research Council (CSIC), Madrid 28006, Spain
Abstract:
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  • Keywords:Taspase1  cancer  proteases  plant-type L-asparaginases  Ntn-hydrolases  X-ray crystallography  anisotropy  intrinsically disordered proteins
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