The Pretreatment Albumin to Globulin Ratio Has Predictive Value for Long-Term Mortality in Nasopharyngeal Carcinoma |
| |
| Authors: | Xiao-Jing Du Ling-Long Tang Yan-Ping Mao Ying Sun Mu-Sheng Zeng Tie-Bang Kang Wei-Hua Jia Ai-Hua Lin Jun Ma |
| |
| Affiliation: | 1. Department of Radiation Oncology, Cancer Center, Sun Yat-sen University, Guangzhou, People’s Republic of China.; 2. State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat-sen University, Guangzhou, People’s Republic of China.; 3. Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, People’s Republic of China.; The University of Hong Kong, China, |
| |
| Abstract: | BackgroundLow serum albumin is predictive of poor survival in nasopharyngeal carcinoma (NPC). We evaluated the ability of the pretreatment albumin/globulin ratio (AGR) to predict long-term mortality in patients with NPC.MethodsThis retrospective study examined an unselected cohort of 694 patients with NPC who had documented pretreatment total serum protein and serum albumin levels (ALB). AGR was calculated as [AGR = ALB/(total serum protein - ALB)]. Survival analysis was used to evaluate the predictive value of AGR.ResultsMultivariate analysis demonstrated that a low pretreatment serum AGR (<1.4) was an independent predictor of poor OS (P = 0.029) and DMFS (P = 0.033). A low AGR was significantly associated with advanced stage disease (P<0.001), high white blood cell count (P = 0.033), high neutrophil count (P = 0.047), high total serum protein (P<0.001) and low ALB (P<0.001).ConclusionThe pretreatment AGR may represent a simple, potentially useful predictive biomarker for evaluating the long-term prognosis of patients with undifferentiated NPC. |
| |
| Keywords: | |
|
|
