Augmentation of B-cell responsiveness by a tumor-activated T-cell factor |
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Authors: | N C Behforouz J Cerny D D Eardley |
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Affiliation: | 1. Department of Microbiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA;2. Department of Microbiology, University of Texas-Medical Branch, Galveston, Texas 77550 USA |
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Abstract: | The growth of the P815 mastocytoma in syngeneic DBA/2 mice led to an activation of Ly1+2- T cells. These T cells produced a soluble factor or factors in culture which, when added to normal spleen cells or B cells in the presence of syngeneic Ly1 cells, caused a genetically unrestricted augmentation of the plaque-forming response toward sheep red blood cells (SRBC). The culture supernatant of the activated T cells did not support the proliferation of an interleukin-2 (IL-2)-dependent cell, nor exhibit properties of late-acting TRF. Active supernatants appeared to affect directly B cells during the first 48 hr of culture with SRBC in such a way as to make them more responsive to antigen-specific Ly1-cell help. |
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Keywords: | To whom correspondence should be addressed. |
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