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Cell-substrate interaction : A method for evaluating the possible correlation between metastatic phenotype and cell surface energy
Authors:S. Reich   H. Rosin   M. Levy   R. Karkash  A. Raz  
Affiliation:1. Department of Plastic Research, The Weizmann Institute of Science, Rehovot 76100, Israel;2. Department of Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
Abstract:The interfacial energy of the non-attached to substrate cell surface was analysed in tumor cell variants of the K-1735 melanoma and UV-2237 fibrosarcoma series, which exhibit distinct metastatic phenotypes. The highly metastatic cell variants exhibited a two-fold increase in the ability to form rapid cell substrate interactions, as compared with their low-metastatic counterparts. These results further highlight the possible role of cell adhesiveness in the process of metastasis.
Keywords:To whom offprint requests should be sent. Address: Department of Cell Biology   The Weizmann Institute of Science   P.O. Box 26   Rehovot 76100   Israel.
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