Anti-atherosclerotic and anti-inflammatory activities of catecholic xanthones and flavonoids isolated from Cudrania tricuspidata |
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| Authors: | Park Ki Hun Park Yong-Dae Han Jong-Min Im Kyung-Ran Lee Byong Won Jeong Il Yun Jeong Tae-Sook Lee Woo Song |
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| Institution: | National Research Laboratory of Lipid Metabolism and Atherosclerosis, Insect Resources Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 3806, Republic of Korea. |
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| Abstract: | The catecholic xanthones and flavonoids 1-13 were isolated from the root bark of Cudrania tricuspidata. Compounds 1 and 3-8 exhibited significant antioxidant activity against low-density lipoprotein (LDL) oxidation in the thiobarbituric acid-reactive substance (TBARS) assay. Among them, prenylated flavonoids 10-12 showed an inhibitory effect on the NO production and iNOS expression in RAW264.7 cells. Also, compounds 1, 2, 5, 7, 9, and 11 preferentially inhibited hACAT-2 than hACAT-1, whereas compounds 3, 4, 6, and 8 showed a similar specificity against hACAT-1 and -2. However, flavonoids 10, 12, and 13 dominantly inhibited hACAT-2, not hACAT-1. |
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