Developmental programming by maternal obesity in 2015: Outcomes,mechanisms, and potential interventions |
| |
| Institution: | 1. Institute of Developmental Sciences, University of Southampton, Southampton, UK;2. NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK;3. Liggins Institute and Office of the Chief Science Advisor to the Prime Minister, University of Auckland, Auckland, New Zealand;4. Family, Women''s and Children''s Health, WHO, Geneva, Switzerland;1. Laboratory of Neuroscience and Nutrition, Department of Biosciences, Federal University of Sao Paulo/UNIFESP, Santos, SP, Brazil;2. Laboratory of Experimental Physical Training, Department of Biosciences, Federal University of Sao Paulo (UNIFESP), Santos, SP, Brazil;3. Laboratory of Neuroscience and Bioprospecting of Natural Products, Department of Biosciences, Federal University of Sao Paulo (UNIFESP), Santos, SP, Brazil;4. Multidisciplinary Laboratory of Food and Health (LabMAS), School of Applied Sciences (FCA), University of Campinas (UNICAMP), Limeira, Sao Paulo, Brazil;1. School of Health and Biomedical Sciences, RMIT University, Melbourne, Vic., 3083, Australia;2. Monash Biomedicine Discovery Institute and Department of Physiology, Monash University, Melbourne, Vic., 3800, Australia;1. FOODplus Research Centre, School of Agriculture, Food & Wine, The University of Adelaide, Adelaide 5064, Australia;2. Sansom Institute, School of Pharmacy and Medical Sciences, University of South Australia, Australia |
| |
| Abstract: | This article is part of a Special Issue “SBN 2014”.Obesity in women of child-bearing age is a growing problem in developed and developing countries. Evidence from human studies indicates that maternal BMI correlates with offspring adiposity from an early age and predisposes to metabolic disease in later life. Thus the early life environment is an attractive target for intervention to improve public health. Animal models have been used to investigate the specific physiological outcomes and mechanisms of developmental programming that result from exposure to maternal obesity in utero. From this research, targeted intervention strategies can be designed. In this review we summarise recent progress in this field, with a focus on cardiometabolic disease and central control of appetite and behaviour. We highlight key factors that may mediate programming by maternal obesity, including leptin, insulin, and ghrelin. Finally, we explore potential lifestyle and pharmacological interventions in humans and the current state of evidence from animal models. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
