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Resveratrol effects in bladder cancer: A mini review
Authors:Tamires Cunha Almeida  Glenda Nicioli da Silva
Affiliation:1.Universidade Federal de Ouro Preto, Laboratório de Pesquisas Clínicas, Ouro Preto, MG, Brazil.
Abstract:Bladder cancer has a high incidence worldwide and is the most common genitourinary cancer. The treatment of bladder cancer involves surgery and chemotherapy; however high failure rates and toxicity are observed. In this context, the search of new drugs aiming a more effective treatment is extremely necessary. Natural products are an important source of compounds with antiproliferative effects. Resveratrol is a naturally occurring plant polyphenol whose anticancer activity has been demonstrated in different types of cancer. This review summarizes the in vitro and in vivo studies using models of bladder cancer treated with resveratrol and discusses its different mechanisms of action.
Keywords:Apoptosis   bladder cancer   cell cycle arrest   cell signalling   resveratrol
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