Effect of triamcinolone administration on content of flavins in rabbit liver |
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| Authors: | ShinIchi Shoji Hiroshi Tsukagoshi Shoko Miyazawa Takashi Hashimoto |
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| Institution: | 1. Department of Medicine (Neurology), Shinshu University School of Medicine, Matsomoto, Japan;2. Department of Biochemistry, Shinshu University School of Medicine, Matsomoto, Japan |
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| Abstract: | Triamcinoline acetonide (10 mg per kg of body weight a day) was administered to rabbit fed on a laboratory chow diet. The content of flavins in liver but not in kidney, muscle and brain started to decrease 24 h after a single dose. The activities of enzymes in the liver were determined: the activities of pyruvate dehydrogenase complex, lipoamide dehydrogenase (NADH : lipoamide oxidoreductase EC 1.6.4.3), NADH dehydrogenase (NADH : (acceptor) oxidoreductace EC 1.6.99.3) and
-amino acid oxidase (
-amino acid : oxygen oxidoreductase (deaminating) EC 1.4.3.3) were decreased but those of succinate dehydrogenase (succinate : (acceptor) oxidoreductase EC 1.3.99.1) and xanthine oxidase (xanthine : oxygen oxidoreductase EC 1.2.3.2) remained unchanged. The activities of enzymes in the kidney, however, remained unchanged except the decrease in the activity of pyruvate dehydrogenase complex. |
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| Keywords: | To whom reprint requests should be addressed |
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