PriA is essential for viability of the Escherichia coli topoisomerase IV parE10(Ts) mutant |
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Authors: | Grompone Gianfranco Bidnenko Vladimir Ehrlich S Dusko Michel Bénédicte |
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Institution: | Laboratoire de Génétique Microbienne, Institut National de la Recherche Agronomique, 78352 Jouy en Josas, France. |
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Abstract: | The parE10(Ts) mutation, which renders Escherichia coli thermosensitive for growth by inactivation of the essential E. coli topoisomerase topo IV, is lethal at all temperatures when PriA, the main replication restart protein, is absent. This lethality is suppressed by the activation of a PriA-independent replication restart pathway (dnaC809 mutation). This result suggests that topo IV acts prior to full-chromosome replication completion. |
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