肉毒毒素抑制剂的研究进展

肉毒毒素(BoNT)是目前已知的毒性最强的生物毒素,肉毒毒素中毒的抗毒素治疗只对未进入神经细胞的毒素有效,而对中毒时间较长、轻链已进入神经系统者无效。近10年来,随着肉毒毒素晶体结构的测定、中毒机理的深入研究,以及体外高通量评价模型的建立,对小分子肉毒毒素抑制剂的研究取得了显著进展。从肉毒毒素中毒机理、结构特征出发,简要综述了肉毒毒素抑制剂的研究进展。

Advance in Botulinum Neurotoxin Inhibitors

Botulinum neurotoxins(BoNT)are the most poisonous biological toxins known to date.Their antitoxin treatments are effective only before BoNT has not entered neuronal cells but noneffective for the long period of intoxication and the toxin's light chain in the nervous system.In the past ten years,the researches of BoNT inhibitors have achieved great progresses along with the determinations of BoNT crystal structures,the further research of reaction mechanisms and the establishments of high-throughput assays.This review mainly focuses on the progress of BoNT inhibitors on the base of the summary of their toxicology and structures.