Template switching: from replication fork repair to genome rearrangements |
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| Authors: | Branzei Dana Foiani Marco |
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| Institution: | FIRC Institute of Molecular Oncology Foundation, Via Adamello 16, 20139 Milan, Italy; Università degli Studi di Milano, Via Celoria 26, 20133 Milan, Italy. dana.branzei@ifom-ieo-campus.it |
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| Abstract: | Genome rearrangements are a hallmark of human genomic disorders and occur largely through recombination mechanisms. In this issue, Lee et al. (2007) show that the complex nonrecurrent rearrangements observed in the dysmyelinating disorder Pelizaeus-Merzbacher disease (PMD) are likely to be caused by a replication mechanism involving template switching. |
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