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Some properties of cryopreserved acute leukemia cells |
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| Authors: | R L Powles L A Balchin C Smith C K Grant |
| Affiliation: | 1. The I.C.R.F. Department of Medical Oncology, St. Bartholomew''s Hospital, EC1 and The Medical Professorial Unit, Institute of Cancer Research, Royal Marsden Hospital, Sutton, Surrey, UK;2. Division of Tumor Immunology, Chester Beatty Research Institute, Laboratories at Clifton Avenue, Belmont, Sutton, Surrey, England |
| Abstract: | We have described a method of cryopreservation of large quantities of human leukemia cells. After storage for long periods the cells retain specific membrane antigens measured using in vitro lymphocyte cultures, and they also functioned suitably as target cells in an immunological assay system. These findings solve some of the logistic problems involved in conducting a large-scale active immunotherapy program for acute leukemia in man. |
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