Inhibition of Lipid Peroxidation of Lecithin Liposomes Kept in a pH-Stat System Near Neutral pH |
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| Authors: | V. Mi&#x í k E. &#x Vajdlenka J. Filí pek D. Gerge K. Ondria&#x |
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| Affiliation: | a Slovak Academy of Sciences, Institute of Experimental Pharmacology, Bratislava, Czechoslovakiab Faculty of Pharmacy, J.A. Comenius University, Bratislavac Research Institute of Gerontology, Malacky, Czechoslovakia |
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| Abstract: | During 5 days of autoxidation of egg lecithin liposomes in nonbuffered saline pH dropped from an initial value of 7.4 to 4.5. A linear relationship between oxidation index and pH was obtained. Lipid peroxidation, monitored as conjugated diene and TBA-reactive products, was inhibited significantly by keep ing the samples under pH-controlled conditions (7.4 plusmn; 0.5), compared to controls. Obtained results indicate that the buffering capacity of Tris and Hepes buffers may play a role in their recently reported (D. Fiorentini et al. (1989) Free Radical Res. Commun., 6, 243) inhibitory action against lipid peroxidation of lecithin liposomes. |
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| Keywords: | Lipid peroxidation buffers pH liposomes |
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