Antiserum Against S-100 Protein Prevents Long Term Potentiation Through a cAMP-Related Mechanism |
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| Authors: | Rebaudo R Melani R Balestrino M Cupello A Haglid K Hydè H |
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| Institution: | (1) Department of Neurological Sciences, University of Genoa, Via De Toni 5, 16132 Genoa, Italy;(2) Center for Cerebral Neurophysiology, C.N.R., Genova, Italy;(3) Institute of Neurobiology, University of Goteborg, Sweden |
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| Abstract: | Long term potentiation (LTP) was induced in the CA1 region of rat hippocampal slices by tetanization of the Schaffer collaterals. Local pretreatment of CA1 with serum of rabbits immunized against S-100 prevented the potentiation. However, treatment of the slices with a membrane permeant cAMP analogue, such as 8-Br-cAMP, could protect against the blocking effect of anti S-100 serum. We suggest that in the rat endogenous S-100b is involved in transduction mechanisms during LTP induction, via its ability to stimulate adenylate cyclase. Possible mechanisms of this action are discussed. |
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