高级别前列腺上皮内瘤（HGPIN）的研究新进展

前列腺上皮内瘤（HGPIN）分为低级别上皮内瘤与高级别上皮内瘤，目前高级别前列腺上皮内瘤是公认的前列腺腺癌的癌前病变，在形态学、遗传学和分子生物学特点上和前列腺癌有许多相似之处。其病因仍不明，临床上影像学检查和实验室检查对其诊断帮助不大，其诊断主要依靠病理组织学检查，包括前列腺穿刺活检与手术切除的组织。免疫组织化学染色应用P504S、P63、34茁E12 有助于和前列腺癌相鉴别。而首次穿刺活检诊断为HGPIN 的患者应定期复查血PSA和定期行增加穿刺针数的活检，是否对HGPIN 行前列腺癌的治疗方法尚存在争议，本文对高级别前列腺上皮内瘤的研究进展做综述如下。

Study Progress Of High-Grade Prostatic Intraepithelial Neoplasia

The classification of prostatic intraepithelial neoplasia includes low-grade prostatic intraepithelial neoplasia （LGPIN） and high-grade prostatic intraepithelial neoplasia. （HGPIN）. HGPIN is a leision which is now believed to be a precursor of prostatic adenocarcinoma, and it has many morphologic, genetic and molecular alterations similar to prostatic adenocarcinoma.The aetiology of HGPIN remains unknown.Currently its diagnosis can only be made by microscopic examination of prostate tissue getting from needle core biopsy or the treatment such as TURP,while the imaging examination and laboratory examination give little help. Immunostaining using P504S, P63 and 3413E12 can distinguish HGPIN from prostatic adenocarcinoma. The patients who were diagnosed HGPIN in the initially prostate biopsy should regularly follow-up the serum PSA and take repeat biopsy with an increasing number of needles. There is a controversy on whether the treatment of prostatic adenocarcinoma can be performed for HGPIN. This article reviewed related progress about HGPIN.