二磷酸盐促进假体周围骨溶解后假体翻修骨整合的实验研究

目的:评价阿仑膦酸钠对新西兰大白兔假体周围发生骨溶解后,再进行对新西兰大白兔假体翻修骨整合的影响。方法:选取雄性新西兰大白兔30只,随机分成3组(正常组,实验组,对照组,每组10只)。正常组在胫骨松质骨区域植入钛合金假体,实验组和对照组分别植入钛合金假体和钛颗粒,饲养8周后,三组统一进行假体翻修。实验组用阿仑磷酸钠治疗8周后取材,对照组和正常翻修组也分别进行取材。通过假体推出力学实验、硬组织切片观察,评价阿仑磷酸钠对假体周围翻修后骨整合的影响。结果:假体推出力学实验结果显示,实验组假体最大推出载荷明显大于对照组(P0.01)。硬组织学切片通过苦味酸--品红染色,利用图像分析仪器统计假体周围骨整合的面积实验组假体周围骨量明显优于对照组假体周围骨量(P0.05)。结论:二磷酸盐-阿仑磷酸钠可以提高假体翻修后假体周围骨整合。

Promote Implant Osteointegration after Wear Particles Induced Osteolysis Revision Operation with Biphosnnate

Objective： To evaluate the alendronate New Zealand white rabbits of periprosthetic osteolysis, renovated New Zealand white rabbits prosthesis osseointegration. Methods： 30 selected male New Zealand white rabbits were randomly divided into three groups （normal control group, the experimental group, the control group, n = 10）.Area of the normal group tibia cancellous bone implanted titanium prosthesis, the experimental and control groups were implanted with a titanium prosthesis and titanium particles 8 weeks, three groups of reunification of the renovation of the prosthesis. Sacrificed after 8 weeks of treatment in the experimental group with alendronate control group and normal group were drawn renovated. Through the the prosthesis launch mechanics experimental hard tissue slice observation, evaluation of the effects of alendronate on periprosthetic renovated osseointegration. Resluts： Prosthesis launched mechanics experimental.Results： Show that the experimental group （alendronate treatment group） prosthesis launched load was significantly greater than the control group （P〈0.01）. Hard histological sections through of picric - Magenta staining using image analysis instrument Statistics periprosthetic osseointegration periprosthetic bone area of the experimental group was significantly better than the control group periprosthetic bone mass （P〈0.05）. Conclusion： Bisphosphonates-alendronate the periprosthetie bone integration can improve the prosthesis renovated.