Trafficking mechanism of water channel aquaporin-2 |
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| Authors: | Noda Yumi Sasaki Sei |
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| Institution: | Department of Nephrology, Tokyo Medical and Dental University, Tokyo 113-8519, Japan. |
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| Abstract: | Targeted positioning of the water channel AQP2 (aquaporin-2) strictly regulates body water homoeostasis. Trafficking of AQP2 to the apical membrane is critical for the reabsorption of water in renal collecting ducts. In addition to the cAMP-mediated effect of vasopressin on AQP2 trafficking to the apical membrane, other signalling cascades can also induce this sorting. Recently, AQP2-binding proteins which could regulate this trafficking have been discovered; SPA-1 (signal-induced proliferation-associated gene-1), a GAP (GTPase-activating protein) for Rap1, and the cytoskeletal protein actin. This review summarizes recent advances related to the trafficking mechanisms of AQP2. |
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| Keywords: | aquaporin‐2 cytoskeleton protein kinase A phosphorylation protein mis‐sorting Rho nephrogenic diabetes insipidus (NDI) |
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