Eukaryotic DNA primase abortive synthesis of oligoadenylates |
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| Authors: | V. N. Podust O. V. Vladimirova E. N. Manakova O. I. Lavrik |
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| Affiliation: | Institute of Bioorganic Chemistry, Siberian Division of the USSR Academy of Sciences, Novosibirsk. |
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| Abstract: | Calf thymus DNA polymerase alpha-primase, human placenta DNA polymerase alpha-primase and human placenta DNA primase synthesized oligoriboadenylates of a preferred length of 2-10 nucleotides and multimeric oligoribonucleotides of a modal length of about 10 monomers on a poly(dT) template. The dimer and trimer were the prevalent products of the polymerization reaction. However, only the oligonucleotides from heptamers to decamers were elongated efficiently by DNA polymerase alpha. |
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| Keywords: | DNA primase DNA polymerase α Primer length |
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