| Preliminary evidence that overexpression of nuclear factor for IL6 expression （NF—IL6） in NIH3T3 cells may be related to malignant transformation |
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| 引用本文： | ZHU MINSHENG, DINGGAN LIU, SHIZUO AKIRA,ZAIPING LI.(Shanghai Institute of Biochemistry,Academic Sinica,Shanghai 200031,China)(Institute of Molecular and Cellular Biology,Osaka University,Japan). Preliminary evidence that overexpression of nuclear factor for IL6 expression （NF—IL6） in NIH3T3 cells may be related to malignant transformation[J]. Cell research, 1994, 4(2): 191-200 |
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| 作者姓名： | ZHU MINSHENG DINGGAN LIU SHIZUO AKIRA ZAIPING LI.(Shanghai Institute of Biochemistry Academic Sinica Shanghai 200031 China)(Institute of Molecular and Cellular Biology Osaka University Japan) |
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| 作者单位： | ZHU MINSHENG; DINGGAN LIU; SHIZUO AKIRA;ZAIPING LI.(Shanghai Institute of Biochemistry，Academic Sinica，Shanghai 200031，China)(Institute of Molecular and Cellular Biology，Osaka University，Japan) |
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| 摘 要： |
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| 关 键 词： | NF－IL6 NIH3T3细胞 肿瘤发生 恶性转化 核因子 过表达 |
Preliminary evidence that overexpression of nuclear factor for IL6 expression (NF-IL6) in NIH3T3 cells may be related to malignant transformation |
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| ZHU MINSHENG, DINGGAN LIU, SHIZUO AKIRA,ZAIPING LI.. Preliminary evidence that overexpression of nuclear factor for IL6 expression (NF-IL6) in NIH3T3 cells may be related to malignant transformation[J]. Cell research, 1994, 4(2): 191-200 |
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| Authors: | ZHU MINSHENG DINGGAN LIU SHIZUO AKIRA ZAIPING LI. |
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| Abstract: | NF-IL6 is a member of c/EBP family and has multiple functions in regulation of cellular gene expression. We have constructed NF-IL6 expression plasmids and trans fected the NIH3T3 cells with them. The sense NF-IL6 transfectants showed significantly increased tumorigenicity, and the stable integration of NF-IL6 cDNA into cellular DNA and its expression were demonstrated. Our results suggest that NF-IL6 may be related to tumorigenesis. |
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| Keywords: | NF-IL6 NIH3T3 tumorigenicity |
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