Synthesis and in vitro cytotoxicity evaluation of some fluorinated hexahydropyrimidine derivatives |
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Authors: | Agbaje Oluropo C Fadeyi Olugbeminiyi O Fadeyi S Adamson Myles Lewis E Okoro Cosmas O |
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Institution: | a Department of Chemistry, Tennessee State University, 3500 John A. Merritt Blvd., Nashville, TN 37209-1561, USA b Department of Biological Sciences, Tennessee State University, 3500 John A. Merritt Blvd., Nashville, TN 37209-1561, USA |
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Abstract: | A series of trifluoromethylated hexahydropyrimidine and tetrahydropyrimidine derivatives were synthesized and their in vitro cytotoxic activities were determined in colon cancer cell line (COLO 320 HSR). Compounds 4f, 4g, 4k, 5, and 7 proved to be the most active in this series of compounds. They represent promising new leads for the development of highly potent and selective anticancer compounds. All the compounds are lipophilic due to the trifluoromethyl group, and are thus expected to penetrate the membrane in appreciable concentration. |
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Keywords: | In vitro cytotoxicity Synthesis Hexahydropyrimidine Tetrahydropyrimidine Trifluoromethyl Stereogenic Polyphosphate ester Colon cancer |
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