Antioxidant activity of a new C-glycosylflavone from the leaves of Ficus microcarpa |
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Authors: | Phan Van Kiem Nguyen Xuan Cuong Nguyen Xuan Nhiem Vu Kim Thu Ninh Khac Ban Chau Van Minh Bui Huu Tai Truong Nam Hai Lee Sang Hyun Jang Hae Dong Kim Young Ho |
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Affiliation: | a College of Pharmacy, Chungnam National University, Daejeon 305-764, Republic of Korea b Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam c Institute of Biotechnology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam d Department of Food and Nutrition, Hannam University, Daejeon 305-811, Republic of Korea |
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Abstract: | By bioactive-guided fractionation of methanol extract of the Ficus microcarpa leaves, one new C-glucosylflavone, ficuflavoside (1), one new megastigmane glycoside, ficumegasoside (8), and twelve known compounds including flavonoids (2-6), phenylpropanoids (7), megastigmanes (9-11) and sterol derivatives (12-14) were isolated. Their chemical structures were elucidated by mass, 1D, and 2D NMR spectroscopies. The antioxidant activities of these compounds were measured using the oxygen radical absorbance capacity methods. Compounds 1-6 exhibited potent antioxidant activities of 6.6-9.5 μM Trolox equivalents at the concentration of 2.0 μM. The results indicated 2, 3, and 5 having meaningful reducing capacity of copper (I) ions concentration of 6.1-8.4 μM. |
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Keywords: | Ficus microcarpa Moraceae Ficuflavoside Ficumegasoside Antioxidant Oxygen radical absorbance capacity |
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