Triazole incorporated pyridazinones as a new class of antihypertensive agents: design, synthesis and in vivo screening |
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| Authors: | Siddiqui Anees A Mishra Ravinesh Shaharyar Mohammad Husain Asif Rashid Mohd Pal Palash |
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| Affiliation: | a Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi 110 062, India
b Pharmacy Department, Faculty of Technology and Engineering, The M.S. University of Baroda, Vadodara 390 001, Gujarat, India |
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| Abstract: | A number of 6-(substituted phenyl)-2-(4-substituted phenyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-4,5-dihydropyridazin-3(2H)-one derivatives were designed and synthesized by a sequence of reactions starting from respective aryl hydrocarbons. The final compounds (4a-4u) were evaluated for antihypertensive activities by non-invasive method using Tail Cuff method. The compounds 4e, 4i and 4k showed appreciable antihypertensive activity comparable with that of standard hydralazine and propranolol. |
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| Keywords: | Pyridazinone 1,2,4-Triazole Antihypertensive activity Non-invasive method |
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