Effect of Thymol on the spontaneous contractile activity of the smooth muscles |
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Authors: | A-M Beer J Lukanov P Sagorchev |
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Institution: | Department of True Naturopathy, Blankenstein Hospital, Im Vogelsang 5-11, 45527 Hattingen, Germany. andre.beer@klinik-Blankenstein.de |
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Abstract: | Effects of Thymol on the spontaneous contractile activity (SCA) have been found in in vitro experiments with circular smooth-muscle strips (SMAs) from guinea pig stomach and vena portae. Thymol was found to possess an agonistic effect on the alpha(1)-, alpha(2)- and beta-adrenergic receptors. Its spasmolytic effect is registered at doses higher than 10(-6)M. Thymol in a dose of 10(-4)M inhibits 100% the SCA of the SMAs and reduces the excitatory effect of 10(-5)M ACH to 35%. It is assumed that Thymol has an analgesic effect through its action on the alpha(2)-adrenergic receptors of the nerve cells. By influencing the beta-adrenergic receptors in the adipose cells, it is possible to induce increased synthesis of fatty acids and glycerol, which is a prerequisite for increased heat release. |
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Keywords: | Smooth muscle fibres Thymol Thymus vulgaris α 1- α 2- and β -adrenergic receptors Papaverine Pain Clonidine |
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