Modulation of serum cortisol by substance P in albino rats: evidence of a direct effect on adrenal gland |
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Authors: | Prasad Anita Naskar Ranu Dubey Rakhi Raha Dipali Ahmed M Firoz |
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Affiliation: | Department of Zoology, Ranchi University, India. |
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Abstract: | Effect of prolonged administration of substance P on the plasma cortisol level in the albino rats has been investigated. An inhibitory impact on intact individuals and a stimulatory effect in pharmacologically annulled rats has been observed. It is concluded that in normal conditions substance P presumably acts as a preventive agent for any excess secretion of cortisol while during stress or disturbed HPA or RAS conditions, it stimulates the secretion of cortisol. An intraglandular modulatory role of substance P has been suggested. |
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