Molecular structure of human lymphocyte receptor for immunoglobulin E |
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| Authors: | H Kikutani S Inui R Sato E L Barsumian H Owaki K Yamasaki T Kaisho N Uchibayashi R R Hardy T Hirano |
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| Affiliation: | 2. Institute for Protein Research Osaka University 3-2, Yamadaoka Suita, Osaka 565 Japan;3. Department of Medicine Osaka University 1-1-50 Fukushima-Ku Osaka 553 Japan;1. University of Dresden, Department of Neurology, Fetscherstrasse 74, 01307 Dresden, Germany;2. GWD Consult, Contract Research, Mozartstrasse 2–4, 63165 Mühlheim am Main, Germany;3. TEVA Pharma GmbH, Charlottenstraße 59, 10117 Berlin, Germany;1. Center of the Spinal Surgery, Nipponbashi Hospital, Osaka-shi, Osaka, Japan;2. Department of Neurosurgery, Kyoto University, Kyoto-shi, Kyoto, Japan;3. Sakuragaoka Pathological Diagnostic Clinic, Kusatu-shi, Shiga, Japan;1. Departamento de Microbiologia e Parasitologia, Instituto de Biologia, Universidade Federal de Pelotas – UFPel, Pelotas, RS, Brazil;2. Núcleo de Tecnologia, Centro de Desenvolvimento Tecnológico, Universidade Federal de Pelotas – UFPel, Pelotas, RS, Brazil;3. Centro Nacional Gado de Corte, Empresa Brasileira de Pesquisa Agropecuária – Embrapa, Campo Grande, MS, Brazil;1. Graduate School of Kuroshio Science, Kochi University, Nankoku, Kochi 783-8502, Japan;2. Fish Disease Laboratory, Department of Aquaculture, Kochi University, Nankoku, Kochi 783-8502, Japan;3. Fish Ecology Laboratory, Department of Aquaculture, Kochi University, Nankoku, Kochi 783-8502, Japan |
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| Abstract: | We have isolated and sequenced a cDNA clone encoding the human lymphocyte receptor for IgE (Fc epsilon R). The deduced protein sequence reveals that Fc epsilon R consists of 321 amino acids, without any signal sequence, and is oriented with its N-terminus on the cytoplasmic side and its C-terminus on the outside of the cell. This molecule shows striking sequence homology with chicken asialoglycoprotein receptor (hepatic lectin), suggesting a possible role for Fc epsilon R in endocytosis. Fc epsilon R mRNA is expressed in B cells, B cell lines, and macrophage cell lines. It is not expressed in T cells or T cell lines, with the exception of an HTLV-transformed T cell line. mRNAs expressed in a macrophage line and in the latter T cell line differ in size from mRNA expressed in B cells. Human BSF-1 (or IL-4) induces the expression of Fc epsilon R mRNA in B cells, but not in T cells. |
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