Histochemical characterization of monoamine oxidase in ependyma of rat hypothalamus |
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Authors: | D. Williams J. E. Gascoigne M. Street E. D. Williams |
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Affiliation: | (1) Department of Pathology, Welsh National School of Medicine, Heath Park, CF4 4XN Cardiff, Wales |
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Abstract: | Sunopsis Monoamine oxidase (MAO) activity has been demonstrated histochemically in rat hypothalamic ependyma using the sulphate-tetrazolium and coupled peroxidatic techniques with tryptamine, tyramine, 5-hydroxytryptamine and benzylamine as substrates. Both methods were applied to cryostat sections with and without exposure to selective amine oxidase inhibitors, including the selective A-MAO inhibitor clorgyline, and the B-MAO inhibitor deprenyl. Our results show that both cuboidal-columnar and tanycyte ependyma contain one or more forms of MAO not generally present in the hypothalamus. It is suggested that ependymal MAO may form an amine-barrier system modulating the movement and effect within the hypothalamus of specific cerebrospinal fluid or blood monoamines. |
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