Binding of [3H] methyltrienolone (R 1881) in rat prostate and human benign prostatic hypertrophy (BPH). |
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| Authors: | J Asselin F Labrie Y Gourdeau C Bonne J P Raynaud |
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| Institution: | Medical Research Council Group in Molecular Endocrinology, Le Centre Hospitalier de l''Université Laval, Québec, G1V 4G2, Canada, L''Hôpital de l''Enfant-Jésus, Québec, and Centre de Recherches Roussel-UCLAF, 93230 Romainville, France |
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| Abstract: | Methyltrienolone (R 1881 - 17beta-hydroxy-17alpha-methyl-estra-4, 9, 11-trien-3-one) binding to rat ventral prostate cytosol has a specificity typical of an androgen receptor. In human benign prostatic hypertrophy (BPH) tissue, the specificity of 3H] R 1881 binding is different from that measured in rat prostate: progesterone and R 5020 (17, 21-dimethyl-19-nor-4, 9-pregnadiene-3, 20-dione) being more potent while 19-nortestosterone is less potent competitor. Moreover, the synthetic progestin 3H] R 5020 binds to BPH tissue with a similar specificity. These data suggest the presence of progestin binding components or of an atypical androgen receptor in human BPH cytosol. |
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| Keywords: | R 1881 methyl trienolone 17β-hydroxy-17α-methyl-estra-4 9 11-trien-3-one DHT androstanolone 5α-dihydrotestosterone = 17β-hydroxy-5α-androstan-3-ne T testosterone 17β-hydroxy-4-androsten-3-one epitestosterone 17α-hydroxy-4-androsten-3-one androstenedione 4-androstene-3 17-dione progesterone 4-pregnene-3 20-dione cyproterone acetate 6-chloro-17α-acetoxy-1 2α-methylene-4 6-pregnadiene-3 20-dione estradiol 1 3 5 (10)-estratriene-3 17β-diol 19-nortestosterone 17β-hydroxy-4-estren-3-one androstanediol 5α-androstane-3α 17β-diol R 5020 17 21-dimethyl-19-nor-4 9-pregnadiene-3 20-dione |
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