DNA repair variants,indoor tanning,and risk of melanoma |
| |
| Authors: | Salina M Torres Li Luo Jenna Lilyquist Christine A Stidley Kristina Flores Kirsten A M White Esther Erdei Melissa Gonzales Susan Paine Rachel I Vogel DeAnn Lazovich Marianne Berwick |
| |
| Institution: | 1. Division of Epidemiology and Biostatistics, University of New Mexico, , Albuquerque, NM, USA;2. Masonic Cancer Center, University of Minnesota, , Minneapolis, MN, USA;3. Division of Epidemiology & Community Health, University of Minnesota, , Minnesota, MN, USA |
| |
| Abstract: | Although ultraviolet radiation (UV) exposure from indoor tanning has been linked to an increased risk of melanoma, the role of DNA repair genes in this process is unknown. We evaluated the association of 92 single nucleotide polymorphisms (SNPs) in 20 DNA repair genes with the risk of melanoma and indoor tanning among 929 patients with melanoma and 817 controls from the Minnesota Skin Health Study. Significant associations with melanoma risk were identified for SNPs in ERCC4, ERCC6, RFC1, XPC, MGMT, and FBRSL1 genes; with a cutoff of P < 0.05. ERCC6 and FBRSL1 gene variants and haplotypes interacted with indoor tanning. However, none of the 92 SNPs tested met the correction criteria for multiple comparisons. This study, based on an a priori interest in investigating the role of DNA repair capacity using variants in base excision and nucleotide excision repair, identified several genes that may play a role in resolving UV‐induced DNA damage. |
| |
| Keywords: | single nucleotide polymorphisms DNA repair indoor tanning melanoma gene– environment interaction artificial UV |
|
|
