Prostaglandin production by methylcholanthrene-transformed mouse BALB/3T3: Inhibition by cytochalasin B |
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Authors: | Sheng-Shung Pong Lawrence Levine |
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Institution: | Department of Biochemistry, Brandeis University Waltham, Massachusetts 02154 USA |
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Abstract: | Cytochalasin B inhibits the production of prostaglandins by serum-, thrombin-, and bradykinin-stimulated MC5-5 cells. The serum-stimulated release of arachidonic acid from cellular phospholipids also is inhibited. Cytochalasin B does not affect the cells' prostaglandin synthetase activity when exogenous arachidonic acid is present. Deacylation of phospholipids may be the step affected by cytochalasin B possibly as a result of disruption of microfilament organization. Colchicine and vinblastine, two drugs that can disrupt microtubule organization, do not inhibit prostaglandin production by cells. |
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