Defective PGE reactivity in leucocytes of multiple sclerosis patients |
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| Authors: | PJ Kirby J Morley JR Ponsford WI McDonald |
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| Institution: | 1. Division of Immunology, Mathilda & Terence Kennedy Institute of Rheumatology, Bute Gardens, Hammersmith, London, UK, W6 7DW;2. Institute of Neurology, Queen Square, London, UK, WC1 3BG |
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| Abstract: | Leucocyte migration inhibition in vitro, in response to antigen or mitogen, is suppressed by PGE2 (0.01–1.0 μg/ml).The susceptibility of leucocytes to such inhibition by PGE2 has been compared using cell preparations obtained from normal individuals, multiple sclerosis patients and from patients with other neurological diseases. The results indicate defective reactivity of leucocytes from multiple sclerosis patients. |
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