The synthesis and antiviral activity of some 4'-thio-2'-deoxynucleoside analogues. |
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| Authors: | M R Dyson P L Coe R T Walker |
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| Affiliation: | School of Chemistry, University of Birmingham, UK. |
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| Abstract: | A practical 7-step synthesis of benzyl 3,5-di-O-benzyl-2-deoxy-1,4-dithio-D-erythro-pentofuranoside is described and the product has been used in the synthesis of some 4'-thio-2'-deoxynucleosides. These novel nucleoside analogues have potentially useful biological activity and are resistant to phosphorolysis. |
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