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Association between ACE I/D polymorphism and pulmonary tuberculosis in Chinese population |
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| Authors: | Yonggang Zhang Xiaobo Li Zhangjun Wu Hong Fan |
| Institution: | 1. Department of Respiratory Medicine, West China Hospital, Sichuan University, Guoxuexiang 37, Chengdu, 610041, Sichuan, China 2. The Periodical Press of West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China 3. Department of Respiratory Medicine, The 452nd Military Hospital, Chengdu, 610041, Sichuan, China 4. Department of Laboratory Medicine, The Tenth Hospital of Chengdu, Chengdu, 610041, Sichuan, China |
| Abstract: | Tuberculosis (TB) remains a global public health problem worldwide. The objective of the current study is to investigate the possible association of ACE I/D polymorphism with pulmonary TB (PTB) for Chinese in Sichuan province. Three hundred eighty-six PTB patients and 398 healthy controls were genotyped to analyze the I/D polymorphism using PCR method. The results showed that the I/D polymorphism was not associated with susceptibility to PTB for Chinese (D vs. I: OR 1.03, 95 % CI 0.84–1.26, and P = 0.77; DD vs. II+DI: OR 1.09, 95 % CI 0.73–1.63, and P = 0.68; DD+DI vs. II: OR 1.00, 95 % CI 0.74–1.33, and P = 0.98). The I/D polymorphism in the ACE gene may not a risk factor for PTB in Chinese. |
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