How Mitochondrial Metabolism Contributes to Macrophage Phenotype and Functions |
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Authors: | Khaddouj Benmoussa Johan Garaude Rebeca Acín-Pérez |
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Institution: | 1. Laboratoire Maladies Rares, Génétique et Métabolisme, INSERM U1211, Université de Bordeaux, CHU Pellegrin, École de Sages-Femmes, 33000 Bordeaux, France;2. UCLA Division of Endocrinology, Diabetes and Metabolism, David Geffen School of Medicine, 10833 Le Conte Avenue, CHS 27-200, Los Angeles, CA 90025, USA;3. Centro Nacional de Investigaciones Cardiovasculares Carlos III, Melchor Fernandez de Almagro 3, 28029 Madrid, Spain |
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Abstract: | Metabolic reprogramming of cells from the innate immune system is one of the most noteworthy topics in immunological research nowadays. Upon infection or tissue damage, innate immune cells, such as macrophages, mobilize various immune and metabolic signals to mount a response best suited to eradicate the threat. Current data indicate that both the immune and metabolic responses are closely interconnected. On account of its peculiar position in regulating both of these processes, the mitochondrion has emerged as a critical organelle that orchestrates the coordinated metabolic and immune adaptations in macrophages. Significant effort is now underway to understand how metabolic features of differentiated macrophages regulate their immune specificities with the eventual goal to manipulate cellular metabolism to control immunity. In this review, we highlight some of the recent work that place cellular and mitochondrial metabolism in a central position in the macrophage differentiation program. |
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