Calorimetric studies of p-nitrophenol binding to α- and β-cyclodextrin |
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Authors: | M R Eftink J C Harrison |
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Institution: | Department of Chemistry, University of Mississippi, University, Mississippi 38677 USA |
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Abstract: | The thermodynamics of the binding of p-nitrophenol to both α- and β-cyclodextrin has been investigated as a function of pH and solvent composition using the technique of flow microcalorimetry. A preferential binding of the anionic form of the ligand is found for both cyclodextrins. It is postulated that the additional affinity for p-nitrophenolate is due to a dispersion interaction between the cyclodextrin cavity and the delocalized charge of the ligand. Studies of the binding of p-nitrophenol analogs and of the binding of p-nitrophenol as a function of ionic strength and DMSO cosolvent composition are consistent with this theory. |
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