Bridging the gap: From protein misfolding to protein misfolding diseases |
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| Authors: | Leila M. Luheshi |
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| Affiliation: | Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK |
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| Abstract: | Protein misfolding and aggregation are pathognomic for a number of the most common age-related degenerative diseases. Great progress has been made in studying protein aggregation in the test tube and also in replicating protein aggregation in vertebrate animal models of these diseases. However, we argue here that the development and effective integration of emerging techniques such as the methods of nanoscience and the use of invertebrate models are now providing powerful new opportunities to advance our current understanding of the fundamental origins of these disorders. |
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| Keywords: | SDS-PAGE, sodium dodecyl sulfate-polyacrylamide gel electrophoresis AD, Alzheimer&rsquo s Disease Aβ, Amyloid Beta APP, Amyloid Precursor Protein AFM, Atomic Force Microscopy TCCD, Two Colour Coincidence Detection QCM, Quartz Crystal Microbalance SEC, Size Exclusion Chromatography FRAP, Fluorescence Recovery After Photobleaching sHsp, small Heat shock protein |
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