Deceptively simple but simply deceptive - Caenorhabditis elegans lifespan studies: Considerations for aging and antioxidant effects |
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| Authors: | Jan Gruber Suresh Kumar Poovathingal |
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| Institution: | a Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
b Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore |
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| Abstract: | The nematode worm Caenorhabditis elegans (C. elegans) is increasingly popular as a model organism for aging studies as well as for testing antioxidants and other compounds for effects on longevity. However, results in the literature are sometimes confusing and contradictory 1], 2], 3] and 4]. This review introduces C. elegans as a model organism, discusses aspects that make it attractive for aging and antioxidant research, and addresses some problems and potential artifacts. |
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| Keywords: | Aging Reactive oxygen species Antioxidant Lifespan Artifact Caenorhabditis elegans |
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