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MicroRNA-21 protects from mesangial cell proliferation induced by diabetic nephropathy in db/db mice |
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| Authors: | Zheng Zhang Huimin Peng Junxia Chen Xin Chen Xiaoming Xu Ning Yan |
| Affiliation: | a Department of Cell Biology and Medical Genetics, Chongqing Medical University, No. 1, Medical College Road, Chongqing, China b Molecular Medicine and Cancer Research Center, Chongqing Medical University, China c Department of Endocrinology, The First Affiliated Hospital, Chongqing Medical University, China |
| Abstract: | Diabetic nephropathy (DN) is a major diabetic complication. But the initiating molecular events triggering DN are unknown. Recent researches have addressed the role of microRNAs in diabetes and its complications. In this study, we looked for microRNAs expression during early DN, and showed microRNA-21 (miR-21) expression was downregulated in response to early DN in vitro and in vivo. Over-expression of miR-21 inhibited proliferation of mesangial cells and decreased the 24-h urine albumin excretion rate in diabetic db/db mice. Moreover, we identified PTEN as a target of miR-21. We also found PI3 K and p-Akt increased in miR-21 treated mesangial cells and db/db mice. Overall, these studies for the first time provide evidence for the potential role of miR-21 in early DN. |
| Keywords: | Diabetic nephropathy Mesangial cell MicroRNAs PTEN phosphohydrolase |
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