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Plasmodium yoelii: Assessment of production and role of nitric oxide during the early stages of infection in susceptible and resistant mice |
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| Authors: | Qing-hui Wang Jun Liu Wei Zheng Ji-chun Wang |
| Institution: | a Department of Immunology, College of Basic Medical Sciences, China Medical University, No. 92 Beier Road, Heping District, Shenyang, China b Department of Pathogenic Biology, College of Basic Medical Sciences, China Medical University, No. 92 Beier Road, Heping District, Shenyang, China c Department of Parasitology, College of Basic Medical Sciences, Jamusi University, Jamusi 154000, China d Department of Laboratory Technology, The General Hospital of Shenyang Military Command, No. 83 Wenhua Road, Shenhe District, Shenyang, China |
| Abstract: | There is conflicting evidence regarding the role of nitric oxide (NO) in the process of resistance against blood-stage malaria parasites. In this study, we used two strains of mice infected with Plasmodium yoelii 17XL in order to assess the NO production profile and its possible role during the early stage of malaria infection. We found a greater elevation of NO production associated with a sharp increase in the levels of IFN-γ in infected DBA/2 mice, compared with infected BALB/c mice. This difference was associated with relatively lower parasitemia, a higher constituent ratio of infected reticulocytes, and greater survival in DBA/2 mice. Endogenous IFN-γ driving Th1 immunity was responsible for NO production. Moreover, schizonts treated in vitro with NO donors caused a delayed infection to BALB/c mice in a dose and time-dependent manner. These data, thus, suggest that NO may play an inhibitory role in Plasmodium infection. |
| Keywords: | NO Plasmodium yoelii During the early stages |
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