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The COPI system: Molecular mechanisms and function
Authors:R. Beck  M. Ravet  F.T. Wieland  D. Cassel
Affiliation:a Yale University School of Medicine, Department of Cell Biology, 333 Cedar Street, SHM C-232, New Haven, CT 06520, USA
b Department of Biology, Technion-Israel Institute of Technology, Haifa 32000, Israel
c Biochemistry Center, Heidelberg University, Im Neuenheimer Feld 328, D-69120 Heidelberg, Germany
Abstract:Transport of membranes and proteins in eukaryotic cells is mediated by vesicular carriers. Here we review the biogenesis and functions of COPI vesicles, carriers that operate in the early secretory pathway. We focus on mechanisms mediating coat recruitment, uptake of cargo, vesicle budding and fission, and finally dissociation of the coat. In this context, recent findings on the interplay between machinery and auxiliary proteins in COPI vesicle formation and function will be discussed. Specifically, we will weigh the pros and cons of recent data on roles of the small GTP binding protein Arf1, of Arf1GAPs, and lipids during COPI carrier formation.
Keywords:COPI   Golgi   Vesicular transport   Arf   Coatomer
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