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Taenia crassiceps cysticercosis: Variations in its parasite growth permissiveness that encounter with local immune features in BALB/c substrains |
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| Authors: | Gabriela Meneses Ingeborg Becker Gabriela Rosas Gladis Fragoso |
| Institution: | a Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Apartado Postal 70228, Mexico City C.P. 04510, Mexico b Facultad de Medicina, Universidad Nacional Autónoma de México, México D.F., Mexico c Facultad de Medicina, Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos, Mexico |
| Abstract: | This study describes the first days of Taenia crassiceps infection in BALB/c substrains, BALB/cAnN and BALB/cJ, using two stocks of the same strains which were kept in different animal facilities, conventional and pathogen-free conditions, respectively. This study shows that parasite growth restriction shown by conventional BALB/cJ mice changed to parasite growth permissiveness when pathogen-free BALB/cJ mice were used. In addition, the higher number of macrophages, NK cells and intraperitoneal level of IFN-γ found in the conventional restrictive BALB/cJ substrain vanished when the permissiveness to the parasite growth increased. No differences were found in DNA sequences of parasites collected before and after the change in the permissiveness to parasite growth which favors the possibility that the observed modifications could be due to changes in the murine strains and/or their maintenance conditions. |
| Keywords: | Taenia crassiceps BALB/c substrains Changes in parasite growth permissiveness Immune features |
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