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Molecular constitution of breast but not other reproductive tissues is rich in growth promoting molecules: A possible link to highest incidence of tumor growths |
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| Authors: | Indira Poola Jessy Abraham Qingqi Yue Lokesh Viswanath Russel Hill George Bonney |
| Institution: | a Department of Biochemistry and Molecular Biology, Howard University College of Medicine, Washington, DC 20059, United States b Department of Surgical Oncology, Howard University College of Medicine, Washington, DC 20059, United States c Department of Pathology, Howard University College of Medicine, Washington, DC 20059, United States d Department of Statistical Genetics and Bioinformatics, Howard University College of Medicine, Washington, DC 20059, United States e Department of Gynecological Oncology, Howard University College of Medicine, Washington, DC 20059, United States f Department of Biochemistry and Molecular Biology, The George Washington University School of Medicine, Washington, DC 20037, United States g Department of Radiation Oncology, Kidwai Memorial Institute of Oncology, Bangalore, India |
| Abstract: | In the current study we tested if highest incidence of benign as well as cancer growths in breast tissue is due to constitutive molecular composition of this tissue. To delineate the molecular basis, we compared the expression of nine functional gene modules (total 578 genes) that regulate major positive growth and negative inhibitory signals in normal breast with two other reproductive tissues, ovary and uterus. We present data to demonstrate that breast tissues constitutively have very highly elevated levels of several growth promoting molecules and diminished levels of inhibitory molecules which may, in part, contribute for highest incidence of tumor growths in this tissue. |
| Keywords: | Breast tissue Constitutive molecular composition Predisposition of tumor growth |
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