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Toxoplasma gondii: Congenital transmission in a hamster model |
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| Authors: | A. Freyre C.G. Fialho F.A.P. Araujo J. Mendez |
| Affiliation: | a Laboratorio de Toxoplasmosis, Departamento de Parasitología, Facultad de Veterinaria, Alberto Lasplaces 1550, Montevideo 11600, Uruguay b Laboratorio de Protozoología, Faculdade de Veterinaria, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil c Laboratorio de Parasitología, Facultad de Química, Montevideo, Uruguay |
| Abstract: | The objective of the research was to test the hamster for a model of transmission of congenital toxoplasmosis. A non-invasive method for the diagnosis of pregnancy in hamsters was designed, with a specificity and a sensitivity of 70.2 and 94.7%, respectively (n = 168). Of 32 females with a chronic toxoplasma infection, 3 transmitted Toxoplasma congenitally during their first pregnancy, but not during the subsequent pregnancy. Congenital transmission rates of infections initiated during pregnancy with 2 stages of 2 strains of Toxoplasma were in the range of 33 to 100% of the 76 females inoculated. Only 1 of 17 females transmitted the parasite exclusively via milk. It was concluded that the hamster is a promising species for a model of transmission of congenital toxoplasmosis. |
| Keywords: | Toxoplasma gondii Congenital transmission Hamster |
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