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Trichinella: Differential expression of angiogenic factors in macrophages stimulated with antigens from encapsulated and non-encapsulated species |
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| Authors: | F. Shariati,J. Ló pez-Abá n,A.R. Martí nez-Ferná ndez |
| Affiliation: | a Laboratorio de Inmunología y Parasitología Molecular, CIETUS, Facultad de Farmacia, Universidad de Salamanca, 37007 Salamanca, Spain b Departamento de Ciencias Médicas y Quirúrgicas, Facultad de Ciencias de la Salud, Universidad de Las Palmas de Gran Canaria, 35080 Las Palmas de Gran Canaria, Spain c Servicio de Hematología, Hospital Clínico Universitario, Salamanca, Spain d Departamento de Parasitología, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain |
| Abstract: | The newborn larval stage of Trichinella spiralis enters the host striated skeletal muscle cell resulting in the formation of the nurse cell. Vascular Endothelial Growth Factor (VEGF) was detected in cells in the area immediately surrounding the nurse cells. However, no data are available on the antigens involved, the role of other angiogenic factors or the relationship of angiogenesis with Nitric Oxide (NO) production.Using macrophage cell culture we study the effect of different Trichinella L1 antigens from one encapsulated (T. spiralis) and one non-encapsulated (Trichinellapseudospiralis) on the expression of VEGF and basic Fibroblast Growth Factor (FGF2). Also, we investigate the relationship between the production of NO and angiogenic mediators. The results show that encapsulated and non-encapsulated Trichinella species are different in their capacity to stimulate the expression of VEGF and FGF2 from host macrophages. Finally, there is no relationship between angiogenic factors and NO production by T. spiralis antigen. |
| Keywords: | Vascular endothelial growth factor Fibroblast growth factor Nitric oxide Alveolar macrophages Trichinella sp. Parasite antigens |
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