Cereblon is expressed in the retina and binds to voltage-gated chloride channels |
| |
| Authors: | Bettina Hohberger |
| |
| Institution: | Institut für Biochemie (Emil-Fischer-Zentrum), Friedrich-Alexander-Universität Erlangen-Nürnberg, Fahrstrasse 17, 91054 Erlangen, Germany |
| |
| Abstract: | The function of the central nervous system depends on the correct regulation of ion channels by interacting proteins. Here, we identified cereblon as a new interactor of the voltage-gated chloride channel ClC-2. A distal region of the ClC-2 C-terminus interacts with the Lon domain of cereblon. Cereblon is expressed in several brain regions including the retina. There, we detected cereblon in nuclear and synaptic layers and localized the protein in the same subcellular region of bipolar cell bodies previously reported to express ClC-2. Our data suggest that cereblon might be associated with voltage-gated chloride channels in the central nervous system.Structured summaryMINT-6823070: CIC-2 (uniprotkb:O54822) physically interacts (MI:0218) with CRBN (uniprotkb:Q0P564) by two hybrid (MI:0018) MINT-6823160, MINT-6823197: CIC-2 (uniprotkb:O54822) physically interacts (MI:0218) with CRBN (uniprotkb:Q56AP7) by pull down (MI:0096) MINT-6823105: CIC-2 (uniprotkb:O54822) physically interacts (MI:0218) with IK (uniprotkb:A4FUY8) by two hybrid (MI:0018) |
| |
| Keywords: | CBS cystathione b-synthase ClC voltage-gated chloride channel CNS central nervous system CRBN cereblon EF1α elongation factor 1α β-Gal β-galactosidase GCL ganglion cell layer GST glutathione S-transferase INL inner nuclear layer IPL inner plexiform layer ONL outer nuclear layer OPL outer plexiform layer PRS photoreceptor segments |
| 本文献已被 ScienceDirect 等数据库收录！ |
