Glucose induces FGF21 mRNA expression through ChREBP activation in rat hepatocytes |
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| Authors: | Katsumi Iizuka Jun Takeda |
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| Institution: | a Department of Diabetes and Endocrinology, Gifu University, Graduate School of Medicine, Gifu 501-1194, Japan
b Laboratory of Medical Genomics, The Institute for Molecular and Cellular Regulation, Gunma University, Maebashi-shi 371-8512, Japan |
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| Abstract: | Fibroblast growth factor 21 (FGF21) has beneficial effects of improving the plasma glucose and lipid profiles in diabetic rodents. Here, we investigated carbohydrate response element binding protein (ChREBP) involvement in the regulation of FGF21 mRNA expression in liver. Glucose stimulation and adenoviral overexpression of dominant active ChREBP increased FGF21 mRNA. Consistently, adenoviral expression of dominant negative Mlx inhibited glucose induction of FGF21 mRNA. Furthermore, deletion studies of mouse FGF21 gene promoter (−2000 to +65 bp) revealed a glucose responsive region between −74 and −52 bp. These findings suggest that FGF21 expression is regulated by ChREBP. |
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| Keywords: | FGF21 fibroblast growth factor 21 ChREBP cabohydrate response elemnt binding protein LPK liver type pyruvate kinase FASN fatty acid synthase |
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