Nucleoside diphosphate kinase-1 regulates hyphal development via the transcriptional regulation of catalase in Neurospora crassa |
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| Authors: | Bumkyu Lee Yusuke Yoshida Kohji Hasunuma |
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| Affiliation: | a Biosafety Division, Department of Agricultural Bio-resources, National Academy of Agricultural Science, Rural Development Administration, 150 Sooin-ro, Seodun-dong, Gwonseon-gu, Suwon 441-707, Republic of Korea
b Kihara Institute for Biological Research, Graduate School of Integrated Science, Yokohama City University, 641-12 Maioka-cho, Totsuka-ku, Yokohama 244-0813, Japan |
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| Abstract: | A nucleoside diphosphate kinase-1-disrupted (ndk-1RIP-1) mutant was observed to be defective in aerial hyphal and conidial development. In this study, two types of hyphae, fine and thick, were observed in wild-type (Wt) strains. However, only fine-type hyphae were observed in the ndk-1RIP-1 mutants. The ndk-1RIP-1 mutants were stimulated by oxidative stress and constitutively expressed an antioxidant enzyme catalase (CAT)-3. Furthermore the ndk-1RIP-1 mutants could form thick hyphae by oxidative stress and a disruption of cat-3. These results suggest that the loss of thick hyphae in the ndk-1RIP-1 mutants may be caused by the over-expression of cat-3. |
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| Keywords: | Catalase Hyphal development Nucleoside diphosphate kinase Reactive oxygen species Neurospora |
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