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The role of mitochondrial palmitate/Ca |
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| Authors: | K. N. Belosludtsev N. V. Belosludtseva G. D. Mironova |
| Affiliation: | (1) Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, ul. Institutskaya 3, Pushchino, Moscow oblast, 142290, Russia;(2) Pushchino State University, pr. Nauki 3, Pushchino, Moscow oblast, 142290, Russia |
| Abstract: | The evidence of possible involvement of the mitochondrial cyclosporin A-insensitive palmitate/Ca2+-activated pore in palmitate-induced apoptosis is presented. It has been established that the opening of the palmitate/Ca2+-activated pore results in the high-amplitude swelling of mitochondria and the release of the apoptosis-inducing factor from organelles. These processes are accompanied by a short-term slight decrease of membrane potential, which recovers in 1 min. The possible role of the palmitate/Ca2+-activated pore in the induction of palmitate-induced apoptosis is discussed. |
| Keywords: | mitochondria palmitate/Ca2+-activated pore apoptosis membrane potential |
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