Novel nikkomycin analogues: inhibitors of the fungal cell wall biosynthesis enzyme chitin synthase |
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| Authors: | Obi K Uda J Iwase K Sugimoto O Ebisu H Matsuda A |
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| Affiliation: | Central Research Laboratories, Kyorin Pharmaceutical Co., Ltd, Tochigi-ken, Japan. |
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| Abstract: | A series of novel nikkomycin analogue inhibitors of the chitin synthase of fungal cell wall was synthesized and evaluated for their inhibitory activities. Among them, the compound having a phenanthrene group at the terminal amino acid was found to possess strong anti-chitin synthase activity. |
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